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PYRIDOstigmine (AChesterase inhibitor used as long-term Rx for MG) Æ increase Ach at NMJ endplate to outcompete MG antibodies ■ Quarternary amines, do not penetrate the CNS: Pogressive proximal weakness, ptosis, diplopia (inactivated nicotinic Ach R at ■ Myasthenia Gravis Æ Ab against nicotinic Ach R motorĮndplate (skeletal muscle NMJ). Organophosphates are a major cause of acute ■ THIOL spray: insecticides (parathion, malathion,Įchothiophate) are organophosphates, a type ofĪcetylcholinesterase inhibitor (also includes nerve agents and Paralysis (NMJ nicotinic Ach receptor over-activation) ■ Acetylcholinesterase inhibitor toxicity includes flaccid Urination, Miosis, Bronchospasm, Bradycardia, Lacrimation, ■ DUMBBELS: acetylcholinesterase inhibitor toxicity (Diarrhea, NMJ (increase activity of NICOTINIC ACh receptors) ■ Acetylcholinesterase inhibitors enhance effects of ACh at the ■ Indirect cholinomimetics (inhibit acetylcholinesterase).Īcetylcholinesterase inhibitors ↑ synaptic “-stigmine” ■ Varenicline (a nicotinic receptor partial agonist) is used for smoking cessationġ.2 – Acetylcholinesterase inhibitors “Stigmata Gravis”
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Contracts bronchial smooth muscle which may ■ Methacholine Æ instigates asthma for pulmonary testing. ■ Carbachol causes pupillary constriction (useful in acute angle-closure glaucoma). Annya’s Sketchy Pharm Credits: Arber Frakulli, Henika Kaura